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pkr (version 0.1.3)

Pharmacokinetics in R

Description

Conduct a noncompartmental analysis as closely as possible to the most widely used commercial software. Some features are 1) CDISC SDTM terms 2) Automatic slope selection with the same criterion of WinNonlin(R) 3) Supporting both 'linear-up linear-down' and 'linear-up log-down' method 4) Interval(partial) AUCs with 'linear' or 'log' interpolation method * Reference: Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016. (ISBN:9198299107).

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Version

Install

install.packages('pkr')

Monthly Downloads

280

Version

0.1.3

License

GPL-3

Maintainer

Last Published

June 11th, 2022

Functions in pkr (0.1.3)

Area Under the Curve(AUC) and Area Under the first Moment Curve(AUMC) by linear trapezoidal method

Get the Slope of regression log(y) ~ x

Convert intermeidate NCA result to adequate unit.

Internal Functions

Noncompartmental analysis for a dataset with multiple subjects

NCA of SDTM data for single subject

Calculate interval AUC

Round Half Away from Zero

Interpolate y value

Do NCA for review

Plot concentration vs. time curve for individuals and collectively.

NCA Report Configuation Table

Read PC domain files

Read EX domain files

Pharmacokinetics in R

Choose best fit slope for the log(y) and x regression by the criteria of adjusted R-square

Internal Functions

Noncompartmental Analysis for an Individual

Load EX and PC domain files in folders

NCA output to pdf file

Disply CDISC standard units and multiplied factor of NCA results

NCA output to rtf file

Forest plot to compare NCA results

Table output NCA

Combine XPT files

Text output of NCA for one subject

Plot best fit slope

Area Under the Curve(AUC) and Area Under the first Moment Curve(AUMC) by linear-up log-down method

Calculate Area Under the Curve (AUC) and Area Under the first Moment Curve (AUMC) in a table format

Internal Functions