pkr (version 0.1.3)

sNCA: Simplest NCA

Description

This is the work-horse function for NCA.

Usage

sNCA(x, y, dose = 0, adm = "Extravascular", dur = 0, doseUnit = "mg", timeUnit = "h", 
     concUnit = "ug/L", iAUC = "", down = "Linear", MW = 0, returnNA = TRUE)

Arguments

x

usually time

y

usually concentration

dose

given amount

adm

one of "Bolus" or "Infusion" or "Extravascular" to indicate drug administration mode

dur

duration of infusion

doseUnit

unit of dose

timeUnit

unit of time

concUnit

unit of concentration

iAUC

interval AUCs to calculate

down

either of "Linear" or "Log" to indicate the way to calculate AUC and AUMC

MW

molecular weight of the drug

returnNA

if returnNA is TRUE, it returns NA values also.

Value

CMAX

maximum concentration, Cmax

CMAXD

dose normalized Cmax, CMAX / Dose, Cmax / Dose

TMAX

time of maximum concentration, Tmax

TLAG

time to observe the first non-zero concentration, for extravascular administration only

CLST

last positive concentration observed, Clast

CLSTP

last positive concentration predicted, Clast_pred

TLST

time of last positive concentration, Tlast

LAMZHL

half-life by lambda z, ln(2)/LAMZ

LAMZ

lambda_z negative of best fit terminal slope

LAMZLL

earliest time for LAMZ

LAMZUL

last time for LAMZ

LAMZNPT

number of points for LAMZ

CORRXY

correlation of log(concentration) and time

R2

R-squared

R2ADJ

R-squared adjusted

C0

back extrapolated concentration at time 0, for bolus intravascular administration only

AUCLST

AUC from 0 to TLST

AUCALL

AUC using all the given points, including trailing zero concentrations

AUCIFO

AUC infinity observed

AUCIFOD

AUCIFO / Dose

AUCIFP

AUC infinity predicted using CLSTP instead of CLST

AUCIFPD

AUCIFP / Dose

AUCPEO

AUC % extrapolation observed

AUCPEP

AUC % extrapolated for AUCIFP

AUCPBEO

AUC % back extrapolation observed, for bolus IV administration only

AUCPBEP

AUC % back extrapolation predicted with AUCIFP, for bolus IV administration only

AUMCLST

AUMC to the TLST

AUMCIFO

AUMC infinity observed using CLST

AUMCIFP

AUMC infinity determined by CLSTP

AUMCPEO

AUMC % extrapolated observed

AUMCPEP

AUMC % extrapolated predicted

MRTIVLST

mean residence time (MRT) to TLST, for intravascular administration

MRTIVIFO

mean residence time (MRT) infinity using CLST, for intravascular administration

MRTIVIFP

mean residence time (MRT) infinity using CLSTP, for intravascular administration

MRTEVLST

mean residence time (MRT) to TLST, for extravascular administration

MRTEVIFO

mean residence time (MRT) infinity using CLST, for extravascular administration

MRTEVIFP

mean residence time (MRT) infinity using CLSTP, for extravascular administration

VZO

volume of distribution determined by LAMZ and AUCIFO, for intravascular administration

VZP

volume of distribution determined by LAMZ and AUCIFP, for intravascular administration

VZFO

VZO for extravascular administration, VZO/F, F is bioavailability

VZFP

VZP for extravascular administration, VZP/F, F is bioavailability

CLO

clearance using AUCIFO, for intravascular administration

CLP

clearance using AUCIFP, for intravascular administration

CLFO

CLO for extravascular administration, CLO/F, F is bioavailability

CLFP

CLP for extravascular administration, CLP/F, F is bioavailability

VSSO

volume of distribution at steady state using CLST, for intravascular administration only

VSSP

volume of distribution at steady state using CLSTP, for intravascular administration only

Details

This will replace IndiNCA.

References

Gabrielsson J, Weiner D. Pharmacokinetic and Pharmacodynamic Data Analysis - Concepts and Applications. 5th ed. 2016.

See Also

help, tblNCA

Examples

# NOT RUN {
# For one subject
x = Theoph[Theoph$Subject=="1","Time"]
y = Theoph[Theoph$Subject=="1","conc"]

sNCA(x, y, dose=320, doseUnit="mg", concUnit="mg/L", timeUnit="h")
sNCA(x, y, dose=320, concUnit="mg/L", returnNA=FALSE)

iAUC = data.frame(Name=c("AUC[0-12h]","AUC[0-24h]"), Start=c(0,0), End=c(12,24))
sNCA(x, y, dose=320, doseUnit="mg", concUnit="mg/L", timeUnit="h", iAUC=iAUC)

MW = 180.164 # Molecular weight of theophylline

sNCA(x, y/MW, dose=320, doseUnit="mg", concUnit="mmol/L", timeUnit="h")
sNCA(x, y/MW, dose=320, doseUnit="mg", concUnit="mmol/L", timeUnit="h", MW=MW)
sNCA(x, y, dose=320/MW, doseUnit="mmol", concUnit="mg/L", timeUnit="h", MW=MW)
sNCA(x, y/MW, dose=320/MW, doseUnit="mmol", concUnit="mmol/L", timeUnit="h", MW=MW)

sNCA(x, y/MW, dose=320/MW, doseUnit="mmol", concUnit="mmol/L", timeUnit="h", MW=MW, 
     returnNA=FALSE)
sNCA(x, y/MW, doseUnit="mmol", concUnit="mmol/L", timeUnit="h", MW=MW, returnNA=FALSE)
sNCA(x, y/MW, dose=as.numeric(NA), doseUnit="mmol", concUnit="mmol/L", timeUnit="h", 
     MW=MW, returnNA=FALSE)

sNCA(x, y, dose=320, concUnit="mg/L", timeUnit="hr")
sNCA(x*60, y, dose=320, concUnit="mg/L", timeUnit="min")
# }