seqmon (version 2.5)

Group Sequential Design Class for Clinical Trials

Description

S4 class object for creating and managing group sequential designs. It calculates the efficacy and futility boundaries at each look. It allows modifying the design and tracking the design update history.

Copy Link

Version

Install

install.packages('seqmon')

Monthly Downloads

210

Version

2.5

License

MIT + file LICENSE

Maintainer

Hui Zheng

Last Published

May 17th, 2024

Functions in seqmon (2.5)

seqmon

Generic function that calculates boundary crossing probabilities used for monitoring clinical trials

summaryDesign

Function that shows the cumulative probabilities for efficacy and futility

setNoncentrality

Function that sets the noncentrality parameter

setTimes

Function that sets the look times

updateDesign

Function that updates the design

printDesign

Function that displays the features of the design

alphaspend

Function that calculates the upper boundaries for efficacy

calcBoundaries

Function for calculating the efficacy and futility boundaries

getProbabilities

Function that calculates the cumulative probabilities to declare efficacy and futility

alphaspendf

The default alpha spending function

betaspendf

The default beta spending function

betaspend

Function that calculates the lower boundaries for futility

plotBoundaries

Function that plots the efficacy and futility boundaries

curtailDesign

Function for calculating the probability for efficacy given known information

setDatestamp

Function that sets the date stamp of the design object

setCurrentLook

Function that sets the current look number

setBaseAlphaspendf

Function that sets the base alpha spending function

setBaseBetaspendf

Function that sets the base beta spending function

curtail

Generic function that calculates the probability to declare efficacy at the end of study given the Z value at the current look

setAlphaspendfString

Function that Sets the expression of the base alpha spending function as a string

sequential.design

The sequential design class

sequential.design-class

Class "sequential.design"

seqmon-package

seqmon

setBetaspendfString

Function that sets the expression of the base beta spending function as a string