The package can identify the dysregulated KEGG pathways based on
global influence from the internal effect of pathways and
crosstalk between pathways.
Description
The package can identify the dysregulated KEGG pathways
based on global influence from the internal effect of pathways
and crosstalk between pathways. (1) The PAGI package can
prioritize the pathways associated with two biological states
by statistical significance or FDR. (2) The PAGI package can
evaluated the global influence factor (GIF) score in the global
gene-gene network constructed based on the relationships of
genes extracted from each pathway in KEGG database and the
overlapped genes between pathways.