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ProNet (version 1.0.0)

Biological Network Construction, Visualization and Analyses

Description

High-throughput experiments are now widely used in biological researches, which improves both the quality and quantity of omics data. Network-based presentation of these data has become a popular way in data analyses. This package mainly provides functions for biological network construction, visualization and analyses. Networks can be constructed either from experimental data or from a set of proteins and integrated PPI database. Based on them, users can perform traditional visualization, along with the subcellular localization based ones for Homo sapiens and Arabidopsis thaliana. Furthermore, analyses including topological statistics, functional module clustering and go profiling can also be achieved.

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Version

Install

install.packages('ProNet')

Monthly Downloads

10

Version

1.0.0

License

GPL (>= 2)

Maintainer

XiaYu Xia

Last Published

October 22nd, 2015

Functions in ProNet (1.0.0)

assemble

Operation of networks
construction

Network construction
construct_nlocal

Non-local network construction
construct_local

Local network construction
enrichment.annotation

GO enrichment annotation
comp.subnet

Comparing a sub network to the whole one
cluster

Network clustering
ath

Arabidopsis thaliana Biogrid PPI database
comp.rand.subnet

Comparing a sub network to the randomly simulated ones
extraction

Subnetwork extraction
GO_process

GO process annotation database
go.profiles

GO enrichment comparison
mcode

MCODE network clustering
HPRD

HPRD PPI database
graph.add

Network union
GO_component

GO component annotation database
human

Homo sapiens Biogrid PPI database
location

Hierarchical plot of biological network
GO_function

GO function annotation database
locDB

Gene products' location database
topology_anc

Average neighborhood connectivity statistics
net.robustness

Network robustness
ProNet-package

Biological Network Construction, Visulization and Analyses
topology_ec

Eigenvector centrality statistics
net.attack

Network attack
topology_degree

Degree statistics
topology_betweenness

Betweenness statistics
net.comparing

Comparing two networks
topology_closeness

Closeness statistics
topology_cluster_coeffi

Clustering coefficient statistics
topology

Network topology analysis
topology_simple

Basic statistics
topology_shortest_paths

Shortest path statistics
visualization

Network visualization