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npde (version 3.5)

Normalised Prediction Distribution Errors for Nonlinear Mixed-Effect Models

Description

Provides routines to compute normalised prediction distribution errors, a metric designed to evaluate non-linear mixed effect models such as those used in pharmacokinetics and pharmacodynamics.

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Version

Install

install.packages('npde')

Monthly Downloads

709

Version

3.5

License

GPL (>= 2)

Maintainer

Emmanuelle Comets

Last Published

February 7th, 2024

Functions in npde (3.5)

npde.plot.select

Select plot for a NpdeObject object
npde.plot.splitcov

Plots split by covariate for a NpdeObject object
theopp

Pharmacokinetics of theophylline
summary.NpdeData

Summary of a NpdeData object
subset.NpdeData

Subsetting a NpdeData object
set.plotoptions

Set graphical preferences
plot.NpdeData

Plots a NpdeData object
virload

Simulated HIV viral loads in HIV patients
pdemenu

Interactive menu to set the options for the npde() function
replace.plotoptions

Replace graphical options
show

Displays npde objects
npde.plot.npde

Plots for pd and npde
plot.NpdeObject

Plots a NpdeObject object
npde.plot.loq

Plot of the probability that the observations are below the LOQ
npde.plot.covariate

Covariate diagnostic plots
npde.plot.scatterplot

Scatterplots and VPC
print.NpdeData

Prints objects from the npde package
npdeControl

Set options for an NpdeObject
npde.plot.data

Plot a NpdeData object
npde.plot.dist

Distribution plots of pd/npde
showall

Contents of an object
npde.save

Save the results contained in a NpdeObject object to a file
npde.graphs

Save the graphs for a NpdeObject object to a file
plot.NpdeRes

Plots a NpdeRes object
read

Read data into structures (internal)
simtheopp

Simulated data for the computation of normalised prediction distribution errors in the theophylline dataset
npdeSimData

Creates a NpdeSimData object
npde.plot.default

Diagnostic plots
npdeData

Creates a NpdeData object
skewness

Skewness
warfarin

Pharmacokinetics of warfarin
dist.pred.sim

Compute distribution of pd/npde using simulations
compute.ploq

Compute P(y_ij<LOQ) for all observations
computenpde

Internal functions used to compute normalised prediction distribution errors (npde)
npde.binning

Internal functions used to produce prediction intervals
autonpde

Compute normalised prediction distribution errors
NpdeData-class

Class "NpdeData" representing the structure of the longitudinal data
NpdeSimData-class

Class "NpdeSimData" representing the structure of the longitudinal data
NpdeObject-class

Class "NpdeObject"
computepd

Internal functions used to compute prediction discrepancies
NpdeRes-class

Class "NpdeRes"
default.npde.plots

Default plots for a NpdeObject object
npde.decorr.method

Decorrelation methods in npde
npde.main

Main npde function
npde.cens.method

Method used to handle censored data
gof.test

Goodness-of-fit tests for npde
[,NpdeSimData-method

Get/set methods for NpdeData object
kurtosis

Kurtosis
npde-package

Normalised prediction distribution errors for nonlinear mixed-effect models