Bayesian Inference of Regulation of Transcriptional Activity
Description
Expression levels of mRNA molecules are regulated by
different processes, comprising inhibition or activation by
transcription factors and post-transcriptional degradation by
microRNAs. birta (Bayesian Inference of Regulation of
Transcriptional Activity) uses the regulatory networks of TFs
and miRNAs together with mRNA and miRNA expression data to
predict switches in regulatory activity between two conditions.
A Bayesian network is used to model the regulatory structure
and Markov-Chain-Monte-Carlo is applied to sample the activity
states.